Beschreibung

PhD Student (m/f/d) in translational cancer research
(Entgeltgruppe: EG 13 TV-L)
Einsatzbereich: Department of Neurosurgery and Spine Surgery - Research Laboratory
Stellen ID: 12333
Eintritt: Next possible date
Umfang: Teilzeit / 25,025 h
Vertragsart: Befristet
Befristung: 29.02.2028; in accordance with § 2 (2) WissZeitVG for the duration of the project.

Ihre Aufgaben:

- Develop your skills on both molecular biology and network science by studying the activity of protein networks in patient-derived glioblastoma samples, with the goal of discovery and preclinical validation of new therapeutic strategies for glioblastoma patients
- Conduct experimental research, including:
- Applying CRISPR technology to patient-derived glioblastoma samples to establish an arrayed screening platform
- Performing classical molecular and cell biology techniques (cell-based assays, protein and nucleic acid analysis)
- Generating and analyzing bulk and single-cell RNA sequencing data
- Characterizing and validating drug-protein network interactions within patient-derived models
- Perform bioinformatic analyses to study glioblastoma biology, including:
- Analyzing transcriptomic data
- Applying machine learning (e.g., Random Forest, XGBoost) and network analysis algorithms (e.g. WGCNA, ARACNe) to large scale data
- Applying concepts from network science and systems biology (e.g., complex adaptive systems (CAS), network controllability) to model and control protein network modules in patient-derived experimental samples
- Develop skills in experimental planning and execution
- Mentoring of undergraduate students
- Data presentation at internal meeting and conferences
- Manuscript writing

Ihr Profil:

- We welcome applications from candidates with a Diploma or Master's degree in natural sciences, computational science, network science, or related fields.
- Experience in wet-lab (Molecular and Cell biology techniques) or bioinformatics (R and/or Python) related to the project is desirableWe welcome applications from candidates with a Diploma or Master's degree in natural sciences, computational, but commitment and strong motivation to learn both aspects is essential
- Fluent in English

Freuen Sie sich auf:

- The opportunity to contribute to translational cancer research with the goal of impacting patient care
- Working in a lab with expertise in the fields of translational cancer research, molecular/cell biology and systems biology: e.g. Nature Medicine 30, 2947 (2024); Nature Communications 12, 3895 (2021); Nature Genetics 49, 708 (2017); Science Translational Medicine 8, 345ra89 (2016).
- Enrollment in the PhD program BIOME [https://www.uni-due.de/biome/](https://www.uni-due.de/biome/) offering structured training and networking opportunities
- Professional training in:
- The execution of translational research projects
- Scientific data presentation and visualization
- Manuscript preparation and publication
- Bringing and developing your own ideas in a collaborative and innovative research environment
- Access to cutting-edge technologies, including Illumina Sequencing and single-cell omics
- A secure job in the public service of the state of NRW
- Fair payment in accordance with the collective wage agreement (TV-L) incl. annual bonus payment and supplementary company pension scheme
- 30 days of vacation per calendar year (for a full-time position)
- Interdisciplinary work with colleagues from other departments
- Working with modern equipment and certified quality standards
- Family-friendly corporate culture, e.g. company daycare center, vacation program for school-age children, advice and support from the Employee Service Office in all life situations
- Wide range of training and continuing education opportunities, e.g. at the Training Academy of UK Essen
- Health Management, e.g. company integration management, vaccinations, promotion of sports activities
- Attractive fringe benefits, e.g. reduced-price canteen meals, community events, accommodation in student residences

Rahmenbedingungen: Die Eingruppierung richtet sich nach den persönlichen und tariflichen Voraussetzungen., Schwerbehinderte Bewerberinnen / Bewerber und Gleichgestellte i.S. des § 2 Abs. 3 SGB IX werden bei gleicher Eignung bevorzugt berücksichtigt., Im Falle einer schriftlichen Bewerbung reichen Sie Ihre Unterlagen nur als unbeglaubigte Kopien ein und verwenden Sie keine Mappen, da keine Rückgabe erfolgt. Eine Vernichtung entlang der datenschutzrechtlichen Bestimmungen wird zugesichert., Das UK Essen strebt eine Erhöhung des Frauenanteils in Bereichen an, in denen Frauen unterrepräsentiert sind. Sie werden zur Bewerbung aufgefordert und im Sinne des LGGs bei gleicher Qualifikation vorrangig berücksichtigt., Eine Bescheinigung gemäß §23a Infektionsschutzgesetz (IfSG) über den Impf- und Serostatus bzgl. Masern ist erforderlich.