55128 Mainz am Rhein - Deutschland
Biologe/Biologin
Arbeit
Vollzeit
ab 08.09.2026
Beschreibung
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented scientists the chance to work on cutting edge research projects. As an IPP PhD student...
Vollständige Beschreibung anzeigen:
Arbeitgeber: Institute of Molecular Biology gGmbH
Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented scientists the chance to work on cutting edge research projects. As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory. The research group of Johannes Mayer offers the following PhD project:Circulating myeloid cells, which include monocytes, dendritic cells and granulocytes, are short lived and continuously replenished by the bone marrow. Under non-inflammatory conditions, myelopoiesis follows relatively ordered differentiation routes that sustain circulating monocytes and granulocytes and seed tissue macrophage and dendritic cell compartments. Both mature cells and bone marrow progenitors have the capacity to rapidly reconfigure during local and systemic inflammation, with cell-cell communication cues from stromal, endothelial, and lymphoid niches helping to calibrate output and function.
Myeloid cell activation and exhaustion has both been described on a mature cell and progenitor cell level, leading to emergency myelopoiesis or hematopoietic halt/shock. Using single-cell and multi-omic profiling integrated with trajectory inference and ligand-receptor/network modeling, this project will establish a perturbation landscape of different myeloid cells and their progenitors in the context of different inflammatory cues using in silico modelling and in vitro validation.
PhD project: Defining Myeloid cell Ageing and its immunological impact on a single cell level
In our lab, we have established an integrated toolkit to study myeloid cell biology at single-cell resolution. Combined with datamining, LLM studies, in vitro activation and CRISPR/Cas9 perturbation screen, you will study the activation and exhaustion landscape of different myeloid cell types and their progenitors. In addition, you will work together with the team to characterize inflammatory models in vivo that span both systemic and local inflammation and track myeloid cell and progenitor activation and exhaustion over time.
This PhD requires a strong background in immunology, previous experience with both wet lab and dry lab work on a single-cell level and a willingness to work with in vivo animal models, including handling, experimental design and tissue processing and analysis.
If you are interested in this project, please select Mayer (Activate) as your project preference in the IPP application platform. Are you an ambitious scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start!
All you need is:
Master or equivalent
Interactive personality & good command of English
2 letters of reference
Exciting, interdisciplinary projects in a lively international environment, with English as our working language
Advanced training in scientific techniques and professional skills
Access to our state-of-the-art Core Facilities and their technical expertise
Fully funded positions with financing until the completion of your thesis
A lively community ofmore than 200 PhD students from 44 different countries
Ref-Nr.: 13337541
Aktualisiert:
11.09.2026
Quelle: Bundesagentur für Arbeit
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Ob die Stelle noch verfügbar ist und weitere Informationen findest du direkt auf der Website der Bundesagentur für Arbeit. Bitte beachte: OPROMA ist nicht der Anbieter dieser Stelle und kann keine Auskünfte geben.
weitere Infos Rechtliche Hinweise zur Nutzung
Ob die Stelle noch verfügbar ist und weitere Informationen findest du direkt auf der Website der Bundesagentur für Arbeit. Bitte beachte: OPROMA ist nicht der Anbieter dieser Stelle und kann keine Auskünfte geben.
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