PhD Position in iPSC-Derived Immune-Competent Lung-on-Chip Infection Modeling (m/f/d)

Universitätsklinikum Jena

07747 Jena - Deutschland

Molekularbiologe/-biologin Arbeit Vollzeit ab 01.10.2025

Beschreibung

Welcome to Jena University Hospital!

We are Thuringia's only university hospital:

Patient care, research and teaching go hand in hand here. We treat more than 520,000 patients every year in our 32 clinics and polyclinics. Their satisfaction is our goal. This is what our more than 7,000 employees work towards every day.

**Primary Duties & Responsibilities:**

- Differentiation of human iPS cells into alveolar epithelial cells (type I and II), endothelial cells, and macrophages
- Establishment of a complex, immune-competent lung model in a microfluidic Organ-on-Chip system with an air-liquid interface
- Development and standardization of an S. aureus infection model
- Design and execution of infection experiments
- Evaluation of nanoparticle-encapsulated antibiotic combinations and development of a multiparametric diagnostic scoring system
- Close collaboration with interdisciplinary project partners from academia and industry
- Preparation of SOPs, data analysis, and support of system integration into an automated diagnostic platform

**Required Skills & Qualifications:**

- Completed university degree (Diploma/Master) in life sciences, molecular biology, biochemistry, biotechnology, or related disciplines
- Practical experience in cell culture, ideally with iPSCs or primary cells
- Experience with microbiological techniques, especially involving pathogenic bacteria (e.g., S. aureus), is advantageous
- Proficiency in molecular biology or imaging techniques (e.g., RT-qPCR, ELISA, immunofluorescence, confocal microscopy)
- Strong interest in translational infection research, organ-on-chip technologies, and interdisciplinary collaboration
- Independent and structured working style with a willingness to learn complex methodologies
- Excellent written and spoken English and German

**We offer you even more:**

- Classification is based on TV-L in pay grade E13. Remuneration is within the salary range (4.600 €- 5.200 € gross ) if the personal and collective agreement requirements are met and corresponds to the classification for full-time employment.
- free continuing education
- company pension
- 30 vacation days

Reference number: DM21/2025

Limited to 30.09.2029

Regardless of origin, age, gender or disability you are welcome here at Jena University Hospital.

Quelle: Bundesagentur für Arbeit - Rechtliche Hinweise zur Nutzung
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