We are seeking a motivated researcher to investigate the molecular pathophysiology of lysosomal and related neurodegenerative diseases and to contribute to the development of novel therapeutic approaches.

Lysosomal diseases are rare, predominantly genetic neurometabolic disorders that often manifest in childhood or adolescence. Despite their genetic heterogeneity, many share converging molecular mechanisms that overlap with classical adult-onset neurodegenerative diseases. These disorders affect both the nervous system and peripheral organs and are clinically characterized by progressive symptoms such as movement disorders, vision and hearing loss, seizures, and cognitive decline. As casual therapies remain unavailable for most lysosomal diseases, this field offers a unique opportunity to drive discoveries with direct translational impact.

Our research group focuses on the molecular characterization of both genetically defined and poorly understood lysosomal diseases, aiming to understand cellular pathology and develop therapeutic strategies. We work with patient-derived cells and human cell models, applying high-throughput techniques such as drug screening to accelerate discovery. Our projects are highly translational, bridging fundamental biology with patient-oriented research and laying the groundwork for future therapeutic development.


Your tasks:

- Investigate the molecular mechanisms and organelle pathology underlying lysosomal diseases (endo-lysosomal trafficking, autophagy, secondary mitochondria disruption)
- Apply and integrate multi-OMICS (transcriptomics, proteomics, metabolomics) approaches to identify dysregulated intracellular pathways and identify therapeutic targets
- Validate targets using genetic and pharmacological perturbations (CRISPR/ Cas9, small molecules) with quantitative functional readouts (enzyme activity, lysosomal flux, imaging)
- Maintain and characterize patient-derived fibroblasts and iPSC models; implement disease-relevant phenotypic assays
- Develop and automate high-throughput compatible assays for drug repurposing screenings; analyze hits and lead follow-up studies
- Collaborate across our Göttingen network; document, present, and publish results; and contribute to reproducible workflows and data sharing initiatives


Your qualification:

- PhD (completed or near completion) in life sciences (e.g., biology, molecular medicine, biochemistry) or a related discipline
- Strong hands-on background in molecular and cell biology with an interest in translational medicine
- Experience in gene editing, multi-omics data integration, or advanced imaging is desirable
- Experience with high-throughput/automation and stem cell (IPSC) models is an advantage, but not mandatory, as these skills can also be developed during the project
- High self-motivation, an independent and creative working style, and excellent teamwork and communication skills


We offer:

- A collaborative neuroscience and translational research environment at the University Medical Center Göttingen (UMG), DZKJ, and Fraunhofer ITMP, with close ties to leading institutions such as the Max Planck Institute for Multidisciplinary Sciences and the DZNE
- Extensive opportunities for interdisciplinary exchange, joint projects, and direct links between basic and clinical research through local, national, and international collaborations
- Secure, multi-source funding (UMG, EU programs, patient organizations, DZKJ) supporting ambitious, long-term projectsAttractive UMG employee benefits, including on-site daycare and vacation childcare, robust health and sports programs, modern infrastructure, and professional development  opportunities
- A beautiful, historic university town with an exceptional concentration of research institutes (University of Göttingen, Max Planck Institutes, German Primate Center, Fraunhofer Institute, German Centers for Health Research (DZG)) and a high quality of life

 

We look forward to receiving your application!