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Scientist / Postdoctoral fellow in functional lymphoma research


Anstellungsart: Limited contract

Arbeitsmodell: Full time

Ausschreibungsnummer: 2234237



Frankfurt University Hospital is one of the leading university hospitals in Germany. More than 8,500 people from over 100 nations work together here toward a common goal. Turning knowledge into health - that is our daily motivation. We combine patient care with research and teaching, embrace progress, and continuously strive to improve ourselves. In doing so, we make an important contribution to the health and quality of life of more than 500,000 patients each year: with expertise, diligence, and passion.
The Department of Hematology and Oncology at the Goethe University Hospital Frankfurt offers the full spectrum of blood and cancer diagnostics and therapy. The DFG Emmy Noether research group of Dr. Sebastian Scheich is part of the Frankfurt Cancer Institute (FCI, https://fci.health) and focuses on aggressive lymphoma biology and signaling. The lab is furthermore funded by grants from philantropy and several governmental organizations, is embedded in a vibrant research environment within the FCI, and maintains lively international collaborations. We apply cutting-edge technologies, including genome-wide CRISPR/Cas9 screens, quantitative functional proteomics, and super resolution microscopy (dSTORM, single molecule tracking, SIM) to dissect oncogenic signaling pathways, study therapy resistance mechanisms, and to find novel therapeutic vulnerabilities. We are looking for a highly motivated postdoctoral researcher to join our team.


The position is limited to three years.


Your Role:



Design, execute, and interpret genome-scale CRISPR/Cas9 screens and functional proteomic approaches, including comprehensive profiling of post-translational modifications
Application and further development of basic and advanced molecular techniques, including advanced cloning, tissue culture, flow cytometry, and protein expression analysis
Intellectual contribution to project direction, complex data analysis, interpretation, and dissemination of results
High degree of scientific independence, including strategic experimental planning, execution, data analysis, and integration of multi-modal datasets within the field of lymphoma research

The applicant is expected to hold a PhD in biology, biochemistry, molecular medicine, or a related field
Strong background and experience in molecular biology methods, such as advanced cloning, mammalian tissue culture, flow cytometry, and protein biochemistry
Hands-on experience in conducting large functional genomic screens and/or proteomic experiments
Experience in bioinformatics and data analysis of proteomic datasets or sequencings is considered advantageous
Confidence and willingness to work with rodent models, ideally with hands-on experience
Very good communication skills in English
Fascination and motivation for biomedical research in the field of cancer biology
Ability to work in a team, sense of responsibility and proactivity
Due to legal regulations, valid proof of measles immunity / measles vaccination is required

In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through a company pension scheme
Funding secured for at least three years and extension possible if needed
Internal and external training for your professional development
Interaction with the National Cancer Institute (Bethesda, USA)
Full access to FCI facilities
Young and enthusiastic working environment in an international, multidisciplinary team
Benefit from our attractive health offers; we offer regular online and face-to-face courses on nutrition, relaxation, sports, and exercise
Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Fa...