Outstanding patient care, award-winning research and teaching and cutting-edge medicine and diagnosis is what defines us, Universitätsklinikum Erlangen. With over 10,000 highly qualified members of staff, we are one of the largest employers in Middle Franconia, and we are still growing steadily. Thanks to the scientific expertise and dedication of our staff, we can offer our patients individual and pioneering treatment options. This is how we can guarantee medical progress. We are confident that you will find a job with us that fits you perfectly, and benefits others as well.

Your tasks:

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| Background of the project: |
| This position is integrated |
| in the research consortium |
| PERCOLATE. The overall aim |
| of PERCOLATE is to establish |
| a rapid and easy-to-use |
| diagnostic test panel, based |
| on detection of functional |
| autoantibodies targeting |
| G-protein coupled receptors |
| (GPCR-fAAb) in combination |
| with GPCR-fAAb mediated |
| ischaemia-reperfusion |
| parameters, accompanied by |
| profiling of immune cells |
| and viral reactivation in |
| patients with Long-COVID (LC) |
| and Post-Vaccination Syndrome |
| (Post-VAC) for a personalized |
| patients’ stratification and |
| care. Your task will be to |
| develop alternative methods |
| to the assay by Wallukat et |
| al., in which primary rat |
| cardiomyocytes were used, to |
| detect the functional active |
| GPCR-AAbs from patients’ |
| sera (~300 samples). Examples |
| of assays are genetically |
| encoded reporter lines or |
| visualization of receptor |
| internalization. The cell |
| system has to be a human |
| system like hiPSC-derived |
| cardiomyocytes but could |
| also be a human standard cell |
| line. In addition, we expect |
| the development of a research |
| project aiming at a better |
| mechanistic understanding of |
| the disease with the focus of |
| the role of autoantibodies (or |
| alternatively a focus that the |
| applicant has experience in; |
| e.g., immune cells). |
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Essential experience/qualifications:

We are seeking a highly motivated and ambitious postdoctoral candidate with a PhD in cell biology, molecular biology, tissue engineering or similar and a strong background in cell and molecular biology with experience in life cell imaging, hiPSCs/hiPSC-cardiomyocytes, autoantibodies, and/or GPCR biology to join our team. Very good English language skills are mandatory.

Additionally beneficial are:

We are seeking a highly motivated and ambitious postdoctoral candidate with a PhD in cell biology, molecular biology, tissue engineering or similar and a strong background in cell and molecular biology with experience in life cell imaging, hiPSCs/hiPSC-cardiomyocytes, autoantibodies, and/or GPCR biology to join our team. Very good English language skills are mandatory.

Comments:

- Funding: The project is funded by the Ministry of Health. Salary: E13, 100% for 2 years with possible extension (funded until 31.12.2028).
- The position can also be done part-time in principle
- The starting date is as soon as possible
- Please provide: CV, Letter of Motivation, Letters of Recommendation, Short proposal regarding your approach to detect functional autoantibodies and a „mechanistic project“(max. 2 pages, not generated by AI).

We offer:

- International team of around 5 postdocs, 10 PhD students and 5 technicians
- Very well-equipped laboratory (several cell culture hoods, epifluorescence and confocal microscopes, everything needed for cell and molecular biology, 3D bioprinters, zebrafish, mouse, rat facilities, and so on).
- Weekly lab meeting and journal club
- Monthly “private meeting with Felix”
- Part of the Translational Research Center embedded in several other institutes including the Max Planck Center for Physics and Medicine.
- Access to significant funds for consumables
- Opportunity to write own internal grants (technician position plus consumables) to gain experience in grant writing and to improve the CV.
- Laboratory is located in the city center.
- A secure, interesting position as part of a motivated, open team
- A thorough and qualified induction, and support in your new challenge.
- Varied and responsible tasks with individual opportunities to grow and develop as a professional
- A wide range of services for promoting a healthy lifestyle
- All public service benefits, including supplementary benefits from the Federal and State
- Government Pension Fund (VBL).
- A family friendly environment and, if applicable, places in University accommodation
- Professional experience can be taken into account when calculating total period of employment

Further information:

Prof. Felix B. Engel
Telefon: -35659

Applications:

Universitätsklinikum Erlangen
Nephropatholgische Abteilung
Prof. Felix B. Engel
Krankenhausstraße 8-10
91054 Erlangen