Beschreibung
Patientenversorgung auf höchstem Niveau, ausgezeichnete Forschung und Lehre sowie modernste Medizin und Diagnostik – das sind wir vom Uniklinikum Erlangen! Mit unseren über 9.800 hoch qualifizierten Beschäftigten sind wir einer der größten Arbeitgeber Mittelfrankens und wachsen stetig weiter. Dank der wissenschaftlichen Expertise und des großen Engagements unserer Mitarbeitenden bieten wir unseren Patientinnen und Patienten einzigartige und zukunftsweisende Behandlungsmöglichkeiten. Damit gewähr...
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Patientenversorgung auf höchstem Niveau, ausgezeichnete Forschung und Lehre sowie modernste Medizin und Diagnostik – das sind wir vom Uniklinikum Erlangen! Mit unseren über 9.800 hoch qualifizierten Beschäftigten sind wir einer der größten Arbeitgeber Mittelfrankens und wachsen stetig weiter. Dank der wissenschaftlichen Expertise und des großen Engagements unserer Mitarbeitenden bieten wir unseren Patientinnen und Patienten einzigartige und zukunftsweisende Behandlungsmöglichkeiten. Damit gewährleisten wir medizinischen Fortschritt. Finden auch Sie bei uns den perfekten Job, der für Sie und andere Sinn ergibt!
Your tasks:
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| Background of the project: |
| This position is integrated |
| in the research consortium |
| PERCOLATE. The overall aim |
| of PERCOLATE is to establish |
| a rapid and easy-to-use |
| diagnostic test panel, based |
| on detection of functional |
| autoantibodies targeting |
| G-protein coupled receptors |
| (GPCR-fAAb) in combination |
| with GPCR-fAAb mediated |
| ischaemia-reperfusion |
| parameters, accompanied by |
| profiling of immune cells |
| and viral reactivation in |
| patients with Long-COVID (LC) |
| and Post-Vaccination Syndrome |
| (Post-VAC) for a personalized |
| patients’ stratification and |
| care. Your task will be to |
| develop alternative methods |
| to the assay by Wallukat et |
| al., in which primary rat |
| cardiomyocytes were used, to |
| detect the functional active |
| GPCR-AAbs from patients’ |
| sera (~300 samples). Examples |
| of assays are genetically |
| encoded reporter lines or |
| visualization of receptor |
| internalization. The cell |
| system has to be a human |
| system like hiPSC-derived |
| cardiomyocytes but could |
| also be a human standard cell |
| line. In addition, we expect |
| the development of a research |
| project aiming at a better |
| mechanistic understanding of |
| the disease with the focus of |
| the role of autoantibodies (or |
| alternatively a focus that the |
| applicant has experience in; |
| e.g., immune cells). |
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Essential experience/qualifications:
We are seeking a highly motivated and ambitious postdoctoral candidate with a PhD in cell biology, molecular biology, tissue engineering or similar and a strong background in cell and molecular biology with experience in life cell imaging, hiPSCs/hiPSC-cardiomyocytes, autoantibodies, and/or GPCR biology to join our team. Very good English language skills are mandatory.
Additionally beneficial are:
We are seeking a highly motivated and ambitious postdoctoral candidate with a PhD in cell biology, molecular biology, tissue engineering or similar and a strong background in cell and molecular biology with experience in life cell imaging, hiPSCs/hiPSC-cardiomyocytes, autoantibodies, and/or GPCR biology to join our team. Very good English language skills are mandatory.
Comments:
- Funding: The project is funded by the Ministry of Health. Salary: E13, 100% for 2 years with possible extension (funded until 31.12.2028).
- The position is temporary for 2 years
- The position is full-time
- The starting date is as soon as possible
- Deadline for applications: 30.04.2026
We offer:
- International team of around 5 postdocs, 10 PhD students and 5 technicians
- Very well-equipped laboratory (several cell culture hoods, epifluorescence and confocal microscopes, everything needed for cell and molecular biology, 3D bioprinters, zebrafish, mouse, rat facilities, and so on).
- Weekly lab meeting and journal club
- Monthly “private meeting with Felix”
- Part of the Translational Research Center embedded in several other institutes including the Max Planck Center for Physics and Medicine.
- Access to significant funds for consumables
- Opportunity to write own internal grants (technician position plus consumables) to gain experience in grant writing and to improve the CV.
- Laboratory is located in the city center.
- A secure, interesting position as part of a motivated, open team
- A thorough and qualified induction, and support in your new challenge.
- Varied and responsible tasks with individual opportunities to grow and develop as a professional
- A wide range of services for promoting a healthy lifestyle
- All public service benefits, including supplementary benefits from the Federal and State
- Government Pension Fund (VBL).
- A family friendly environment and, if applicable, places in University accommodation
- Professional experience can be taken into account when calculating total period of employment
Further information:
Prof. Felix B. Engel
Telefon: -35659
Applications:
Nephropatholgische Abteilung
Prof. Felix B. Engel
Telefon: -35659
E-Mail: felix.engel@uk-erlangen.de
Please provide: CV, Letter of Motivation, Letters of Recommendation, Short proposal regarding your approach to detect functional autoantibodies and a „mechanistic project“(max. 2 pages, not generated by AI).